PS251. Pharmacological suppression of the lateral habenula via the activation of mu opioid receptors ameliorate helpless behaviors in a rodent model of depression

s | 91 Methods: Forty-five right-handed patients with PD who met the diagnostic criteria in Structured Clinical Interview for DSM-V and twenty-two healthy control were examined by means of MRI at 3 Tesla. We used the FreeSurfer software package to create a three-dimensional model of the cortical surface for estimating the cortical thickness. In order to test the effect of the gene polymorphism on the brain cortical thickness, we were evaluated their candidate gene polymorphisms of 5-HTTLPR, HTR1A, COMT, BDNF and RGS. We examined between-group differences in cortical thickness using a 2 × 2 analysis of covariance (ANCOVA) to control age, gender, and education. Results: We found scores of cortical thickness of PD is significantly lower than those of HC in temporal pole(p=0.000) and insula(p=0.000). Furthermore, analyses of covariance controlling for age, gender and education showed an interaction effects of the genes polymorphisms-by-panic disorder on paralimbic area. 5-HTTLPR rs25531(p=0.011, Lt, temporal pole; p=0.011, Lt, insula), HTR1A rs6295(p=0.007, Lt, temporal pole; p=0.002; Lt, insula; p=0.031, Lt, rostral anterior cingulate), BDNF rs6265 (p=0.012, Lt, temporal pole; p=0.002; Lt, insula), COMT rs4680 (p=0.000, Lt, temporal pole; p=0.001; Lt, insula), RGS2 rs4606(p=0.009, Lt, temporal pole; p=0.009; Lt, insula; p=0.034).